The center's exhibits cover historic, prehistoric, and paleontological subjects. Exhibit topics include archaeology, the Cheyenne-Deadwood Stage Route, mining, the Texas Trail, emigrant trails, Spanish Diggings, and paleontology. Collections include regional materials ranging from Cretaceous fossils, Pleistocene mammoths, and Paleoindian artifacts to a variety of historical objects, records, and oral histories.

Located in Thermopolis, the Wyoming Dinosaur Center features interpretive displays, dioramas, and life-size dinosaur mounts. It has 12,000 square feet of exhibition area. Fossils and life-forms from earliest geologic time periods are displayed in a time-perspective. There are over 200 displays throughout the museum. The central hall houses 20 full-size mounted skeletons, including 10 dinosaurs. There are also over 60 identified active digsites in a 500-acre area. They also offer Kids' Digs.

Located near Kemmerer, Fossil Butte National Monument is a 50-million year old lake bed and one of the richest fossil localities in the world. Recorded in limestone are dynamic and complete paleoecosystems that spanned two million years. Preservation is so complete that it allows for detailed study of climate change and its effects on biological communities. Visitors discover that this resource displays the interrelationships of plants, insects, fishes, reptiles and mammals, like few other known fossil sites. The relevance and challenge of study and preservation of this ancient ecosystem are equal to those of a modern ecosystem. The surface topography of Fossil Butte is now covered by a high cold desert. Sagebrush is the dominant vegetation at the lower elevations, while limber pine and aspen occur on the slopes. Pronghorn, Mule deer and a variety of birds are commonly seen. Moose, elk and beaver are sometimes observed.

Family style learning is a great way to tackle lots of different subjects, including science.